Determining cost and placement decisions for moderate complexity NAATs for tuberculosis drug susceptibility testing

ABSTRACT:

Background

Access to drug resistant testing for tuberculosis (TB) remains a challenge in high burden countries. Recently, the World Health Organization approved the use of several moderate complexity automated nucleic acid amplification tests (MC-NAAT) that have performance profiles suitable for placement in a range of TB laboratory tiers to improve drug susceptibility tests (DST) coverage.

Methods

We conducted cost analysis of two MC-NAATs with different testing throughput: Lower Throughput (LT, < 24 tests per run) and Higher Throughput (HT, upto 90+ tests per run) for placement in a hypothetical laboratory in a resource limited setting. We used per-test cost as the main indicator to assess 1) drivers of cost by resource types and 2) optimized levels of annual testing vo

SUBMITTER: Malhotra A 

PROVIDER: S-EPMC10449112 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature