Non-asymptotic transients away from steady states determine cellular responsiveness to dynamic spatial-temporal signals.

ABSTRACT: Majority of the theory on cell polarization and the understanding of cellular sensing and responsiveness to localized chemical cues has been based on the idea that non-polarized and polarized cell states can be represented by stable asymptotic switching between them. The existing model classes that describe the dynamics of signaling networks underlying polarization are formulated within the framework of autonomous systems. However these models do not simultaneously capture both, robust maintenance of polarized state longer than the signal duration, and retained responsiveness to signals with complex spatial-temporal distribution. Based on recent experimental evidence for criticality organization of biochemical networks, we challenge the current concepts and demonstrate that non-asymptotic

SUBMITTER: Nandan A 

PROVIDER: S-EPMC10449117 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature