Drosophila embryos allocate lipid droplets to specific lineages to ensure punctual development and redox homeostasis.

ABSTRACT: Lipid droplets (LDs) are ubiquitous organelles that facilitate neutral lipid storage in cells, including energy-dense triglycerides. They are found in all investigated metazoan embryos where they are thought to provide energy for development. Intriguingly, early embryos of diverse metazoan species asymmetrically allocate LDs amongst cellular lineages, a process which can involve massive intracellular redistribution of LDs. However, the biological reason for asymmetric lineage allocation is unknown. To address this issue, we utilize the Drosophila embryo where the cytoskeletal mechanisms that drive allocation are well characterized. We disrupt allocation by two different means: Loss of the LD protein Jabba results in LDs adhering inappropriately to glycogen granules; loss of Klar alters the

SUBMITTER: Kilwein MD 

PROVIDER: S-EPMC10449164 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature