Development and validation of an individual-based state-transition model for the prediction of frailty and frailty-related events.

ABSTRACT: Frailty is a biological syndrome that is associated with increased risks of morbidity and mortality. To assess the value of interventions to prevent or manage frailty, all important impacts on costs and outcomes should be estimated. The aim of this study is to describe the development and validation of an individual-based state transition model that predicts the incidence and progression of frailty and frailty-related events over the remaining lifetime of older Australians. An individual-based state transition simulation model comprising integrated sub models that represent the occurrence of seven events (mortality, hip fracture, falls, admission to hospital, delirium, physical disability, and transitioning to residential care) was developed. The initial parameterisation used data from the

SUBMITTER: Pincombe A 

PROVIDER: S-EPMC10449188 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature