Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage.

ABSTRACT:

Background

Renal injury induces major changes in plasma and cardiac metabolites. Using a small- animal in vivo model, we sought to identify a key metabolite whose levels are significantly modified following an acute kidney injury (AKI) and to analyze whether this agent could offer cardiac protection once an ischemic event has occurred.

Methods and results

Metabolomics profiling of cardiac lysates and plasma samples derived from rats that underwent AKI 1 or 7 days earlier by 5/6 nephrectomy versus sham-operated controls was performed. We detected 26 differential metabolites in both heart and plasma samples at the two selected time points, relative to sham. Out of which, kynurenic acid (kynurenate, KYNA) seemed most relevant. Interestingly, KYNA given at 10 mM concentration si

SUBMITTER: Bigelman E 

PROVIDER: S-EPMC10449225 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature