Deciphering the crosstalk of immune dysregulation between COVID-19 and idiopathic inflammatory myopathy

ABSTRACT:

Background

The coronavirus disease (COVID-19) pandemic is a serious threat to public health worldwide. Growing evidence reveals that there are certain links between COVID-19 and autoimmune diseases; in particular, COVID-19 and idiopathic inflammatory myopathies (IIM) have been observed to be clinically comorbid. Hence, this study aimed to elucidate the molecular mechanisms of COVID-19 and IIM from a genomic perspective.

Methods

We obtained transcriptome data of patients with COVID-19 and IIM separately from the GEO database and identified common differentially expressed genes (DEGs) by intersection. We then performed functional enrichment, PPI, machine learning, gene expression regulatory network, and immune infiltration analyses of co-expressed genes.

Results

A

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10449257 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature