Comprehensive analysis of the oncogenic and immunological role of FAP and identification of the ceRNA network in human cancers.

ABSTRACT: Fibroblast activation protein-alpha (FAP) is a transmembrane serine protease involving in tissue remodeling. Previous studies report that FAP is highly expressed in certain tumors and participated in oncogenesis. However, there is still lack of systematic and in-depth analysis of FAP based on clinical big data. Here, we comprehensively map the FAP expression profile, prognostic outcome, genetic alteration, immune infiltration across over 30 types of human cancers through multiple datasets including TCGA, CPTAC, and cBioPortal. We find that FAP is up-regulated in most cancer types, and increased FAP expression is associated with advanced pathological stages or poor prognosis in several cancers. Furthermore, FAP is significantly correlated with the infiltration of cancer-associated fibroblas

SUBMITTER: Mai W 

PROVIDER: S-EPMC10449273 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature