Comprehensive analyses reveal the prognosis and biological function roles of chromatin regulators in lung adenocarcinoma.

ABSTRACT: The present study explored the prognosis and biological function roles of chromatin regulators (CRs) in patients with lung adenocarcinoma (LUAD). Using transcriptome profile and clinical follow-up data of LUAD dataset, we explored the molecular classification, developed, and validated a CR prognostic model, built an individual risk scoring system in LUAD, and compared the clinical and molecular characteristics between different subtypes and risk stratifications. We investigated the chemotherapy sensitivity and predicted potential immunotherapy response. Lastly, we collected the clinical samples and validated the prognosis and potential function role of NAPS2. Our study indicated that LUAD patients could be classified into two subtypes that had obviously different clinical background and mo

SUBMITTER: Yang B 

PROVIDER: S-EPMC10449281 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature