Proteostatic modulation in brain aging without associated Alzheimer's disease-and age-related neuropathological changes.

ABSTRACT:

Aims

(Phospho)proteomics of old-aged subjects without cognitive or behavioral symptoms, and without AD-neuropathological changes and lacking any other neurodegenerative alteration will increase understanding about the physiological state of human brain aging without associate neurological deficits and neuropathological lesions.

Methods

(Phospho)proteomics using conventional label-free- and SWATH-MS (Sequential window acquisition of all theoretical fragment ion spectra mass spectrometry) has been assessed in the frontal cortex (FC) of individuals without NFTs, senile plaques (SPs) and age-related co-morbidities classified by age (years) in four groups; group 1 (young, 30-44); group 2 (middle-aged: MA, 45-52); group 3 (early-elderly, 64-70); and group 4 (late-elderly, 75-85).<

SUBMITTER: Andres-Benito P 

PROVIDER: S-EPMC10449282 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature