Biological and immunological significance of DLL3 expression in different tumor tissues: a pan-cancer analysis.

ABSTRACT:

Objective

To evaluate the biological and immunological significance of DLL3 expression in different tumor tissues and provide insight into the role of DLL3 in tumor immunotherapy.

Material and methods

RNA expression and clinical data of The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) were acquired, and we employed couple of bioinformatics methods to investigate the potential biological and immunological role DLL3, including pan-cancer expression, survival analysis, GSVA and it's correlation with immune infiltration scores, tumor mutation burden, tumor microsatellite instability.

Results

The findings indicate that DLL3 is expressed in the majority of tumors but is only weakly prevalent in HNSC. In 18 different types of cancers, DLL3 expression was

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10449286 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature