MGME1 associates with poor prognosis and is vital for cell proliferation in lower-grade glioma.

ABSTRACT:

Objective

Mitochondrial genome maintenance exonuclease 1 (MGME1) is associated with DNA depletion, deletion, duplication, and rearrangement. However, the function of MGME1 in tumors, especially lower-grade gliomas (LGGs), has not been established.

Methods

Pan-cancer analysis was used to define the expression patterns and prognostic value of MGME1 in various cancers. Subsequently, we systematically determined the associations between MGME1 expression and clinicopathological characteristics, prognosis, biological functions, immune characteristics, genomic mutations, and therapeutic responses of LGGs based on their expression patterns. The expression level and specific functions of MGME1 in LGGs was detected by conducting in vitro experiments.

Results

Abnormally e

SUBMITTER: Xiao F 

PROVIDER: S-EPMC10449294 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature