Genistein exerts anti-colorectal cancer actions: clinical reports, computational and validated findings.

ABSTRACT: Colorectal cancer (CRC) is presently a health challenge in China. Although clinical chemotherapy is prescribed availably, the negative effects and poor prognoses still occur. Genistein has antitumor properties in our previous studies. However, the molecular mechanisms underlying the anti-CRC effects of genistein remain unclear. Increasing evidences have indicated that the induction of autophagy, one of cell death models, is closely associated with the formation and development of human cancer. In the current study, a systematic bioinformatics approach using network pharmacology and molecular docking imitation was aimed at identifying the pharmacological targets and anti-CRC mechanisms of genistein, characterized by autophagy-related processes and pathways. Moreover, experimental validation

SUBMITTER: Liu X 

PROVIDER: S-EPMC10449307 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature