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Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours.

ABSTRACT: Curcuphenol, a common component of the culinary spices, naturally found in marine invertebrates and plants, has been identified as a novel candidate for reversing immune escape by restoring expression of the antigen presentation machinery (APM) in invasive cancers, thereby resurrecting the immune recognition of metastatic tumours. Two synthetic curcuphenol analogues, were prepared by informed design that demonstrated consistent induction of APM expression in metastatic prostate and lung carcinoma cells. Both analogues were subsequently found to possess a previously undescribed histone deacetylase (HDAC)-enhancing activity. Remarkably, the H3K27ac ChIPseq analysis of curcuphenol-treated cells reveals that the induced epigenomic marks closely resemble the changes in genome-wide pattern observed with interferon-γ, a cytokine instrumental for orchestrating innate and adaptive immunity. These observations link dietary components to modifying epigenetic programs that modulate gene expression guiding poised immunity.

SUBMITTER: Ellis SLS

PROVIDER: S-EPMC10449465 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours.

Ellis Samantha L S SLS Dada Sarah S Nohara Lilian L LL Saranchova Iryna I Munro Lonna L Pfeifer Cheryl G CG Eyford Brett A BA Morova Tunc T Williams David E DE Cheng Ping P Lack Nathan A NA Andersen Raymond J RJ Jefferies Wilfred A WA

Frontiers in pharmacology 20230810

Curcuphenol, a common component of the culinary spices, naturally found in marine invertebrates and plants, has been identified as a novel candidate for reversing immune escape by restoring expression of the antigen presentation machinery (APM) in invasive cancers, thereby resurrecting the immune recognition of metastatic tumours. Two synthetic curcuphenol analogues, were prepared by informed design that demonstrated consistent induction of APM expression in metastatic prostate and lung carcinom ...[more]

PMID: 37637416

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Dataset Information

Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours.

Publications

Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours.

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