A revised SNP-based barcoding scheme for typing Mycobacterium tuberculosis complex isolates.

ABSTRACT: The development of whole-genome sequencing technologies is gradually leading to a more detailed description of the population structure of the Mycobacterium tuberculosis complex (MTBC). In this study, we correlated previously published classifications on a collection of more than 10,000 genomes and proposed a new, comprehensive nomenclature that unifies the existing ones. In total, we identified 169 lineages and sublineages of M. tuberculosis/M. africanum and 9 animal-adapted species. For the purpose of organizing these genotypes in a more streamlined manner, we stratified them into five hierarchical levels. To represent the classification and compare it with the reference, we compiled a confirmatory data set of 670 high-quality isolates, which includes all genotypes a

SUBMITTER: Shitikov E 

PROVIDER: S-EPMC10449489 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature