Development of the Shigella flexneri 2a, 3a, 6, and S. sonnei artificial Invaplex (Invaplex_AR) vaccines.

ABSTRACT: The Shigella artificial invasin complex (Invaplex_AR) vaccine is a subunit approach that effectively induces robust immunogenicity directed to serotype-specific lipopolysaccharide and the broadly conserved IpaB and IpaC proteins. One advantage of the vaccine approach is the ability to adjust the constituents to address suboptimal immunogenicity and to change the Shigella serotype targeted by the vaccine. As the vaccine moves through the product development pipeline, substantial modifications have been made to address manufacturing feasibility, acceptability to regulatory authorities, and developing immunogenic and effective products for an expanded list of Shigella serotypes. Modifications of the recombinant clones used to express affinity tag-free proteins u

SUBMITTER: Turbyfill KR 

PROVIDER: S-EPMC10449495 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature