The C₂H₂ transcription factor SltA is required for germination and hyphal development in Aspergillus fumigatus.

ABSTRACT: Germination of inhaled Aspergillus fumigatus conidia is a necessary sequitur for infection. Germination of conidia starts with the breaking of dormancy, which is initiated by an increase of the cellular perimeter in a process termed isotropic growth. This swelling phase is followed by polarized growth, resulting in the formation of a germ tube. The multinucleate tubular cells exhibit tip growth from the hyphae, after which lateral branches emerge to form the mycelial network. The regulatory mechanisms governing conidial germination are not well defined. In this study, we identified a novel role for the transcription factor SltA in the orchestration of germination and hyphal development. Conidia lacking sltA fail to appropriately regulate isotropic growth and begin to swell ea

SUBMITTER: Baltussen TJH 

PROVIDER: S-EPMC10449517 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature