Impact of hyperparathyroidism and its different subtypes on long term graft outcome: a single Transplant Center cohort study.

ABSTRACT:

Purpose

We studied the association between parathormone (PTH) levels and long-term graft loss in RTx patients (RTx-p).

Methods

We retrospectively evaluated 871 RTx-p, transplanted in our unit from Jan-2004 to Dec-2020 assessing renal function and mineral metabolism parameters at 1, 6, and 12 months after RTx. Graft loss and death with functioning graft during follow-up (FU, 8.3[5.4-11.4] years) were checked.

Results

At month-1, 79% had HPT, of which 63% with secondary HPT (SHPT) and 16% tertiary HPT (THPT); at month-6, HPT prevalence was 80% of which SHPT 64% and THPT 16%; at month-12 HPT prevalence was 77% of which SHPT 62% and THPT 15%. A strong significant correlation was found between HPT type, PTH levels and graft loss at every time point. Mean PTH exposure remai

SUBMITTER: Molinari P 

PROVIDER: S-EPMC10449540 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature