Characterisation of cell lines derived from prostate cancer patients with localised disease.

ABSTRACT:

Background

Prostate cancer is a broad-spectrum disease, spanning from indolent to a highly aggressive lethal malignancy. Prostate cancer cell lines are essential tools to understanding the basic features of this malignancy, as well as in identifying novel therapeutic strategies. However, most cell lines routinely used in prostate cancer research are derived from metastatic disease and may not fully elucidate the molecular events underlying the early stages of cancer development and progression. Thus, there is a need for new cell lines derived from localised disease to better span the disease spectrum.

Methods

Prostatic tissue from the primary site, and adjacent non-cancerous tissue was obtained from four patients with localised disease undergoing radical prostatectomy. Epith

SUBMITTER: Moya L 

PROVIDER: S-EPMC10449630 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature