Delayed acquisition of airway commensals in antibiotic naive children and its relationship with wheezing in rural Ecuador.

ABSTRACT:

Introduction

The hygiene hypothesis identified a relationship between living in rural areas and acquiring protective environmental factors against the development of asthma and atopy. In our previous study, we found a correlation between particular bacterial species and early-onset wheezing in infants from the rural tropics of Ecuador who were corticosteroid-naïve and had limited antibiotic exposure. We now describe a longitudinal study of infants conducted to determine the age-related changes of the microbiome and its relationship with wheezing.

Methods

We performed an amplicon sequencing of the 16S rRNA bacterial gene from the oropharyngeal samples obtained from 110 infants who had a history of recurrent episodic wheezing sampled at different ages (7, 12, and 24 months) an

SUBMITTER: Cardenas PA 

PROVIDER: S-EPMC10449644 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature