Phenome-wide genetic-correlation analysis and genetically informed causal inference of amyotrophic lateral sclerosis.

ABSTRACT: Leveraging genome-wide association statistics generated from a large study of amyotrophic lateral sclerosis (ALS; 29,612 cases and 122,656 controls) and UK Biobank (UKB; 4,024 phenotypes, up to 361,194 participants), we conducted a phenome-wide analysis of ALS genetic liability and identified 46 genetically correlated traits, such as fluid intelligence score (r_g = - 0.21, p = 1.74 × 10^-6), "spending time in pub or social club" (r_g = 0.24, p = 2.77 × 10^-6), non-work related walking (r_g = - 0.25, p = 1.95 × 10^-6), college education (r_g = - 0.15, p = 7.08 × 10^-5), "ever diagnosed with panic attacks (r_g = 0.39, p = 4.24 × 10^-5), and "self-reported other gastritis including duodenitis"

SUBMITTER: D'Antona S 

PROVIDER: S-EPMC10449723 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature