Reduced cortical neuron number and neuron density in schizophrenia with focus on area 24: a post-mortem case-control study.

ABSTRACT: Structural and functional abnormalities of the anterior cingulate cortex (ACC) have frequently been identified in schizophrenia. Alterations of von Economo neurons (VENs), a class of specialized projection neurons, have been found in different neuropsychiatric disorders and are also suspected in schizophrenia. To date, however, no definitive conclusions can be drawn about quantitative histologic changes in the ACC in schizophrenia because of a lack of rigorous, design-based stereologic studies. In the present study, the volume, total neuron number and total number of VENs in layer V of area 24 were determined in both hemispheres of postmortem brains from 12 male patients with schizophrenia and 11 age-matched male controls. To distinguish global from local effects, volume and total neuron n

SUBMITTER: Gaus R 

PROVIDER: S-EPMC10449727 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature