Predicting [¹⁷⁷Lu]Lu-HA-DOTATATE kidney and tumor accumulation based on [⁶⁸Ga]Ga-HA-DOTATATE diagnostic imaging using semi-physiological population pharmacokinetic modeling.

ABSTRACT:

Background

Prediction of [¹⁷⁷Lu]Lu-HA-DOTATATE kidney and tumor uptake based on diagnostic [⁶⁸Ga]Ga-HA-DOTATATE imaging would be a crucial step for precision dosing of [¹⁷⁷Lu]Lu-HA-DOTATATE. In this study, the population pharmacokinetic (PK) differences between [¹⁷⁷Lu]Lu-HA-DOTATATE and [⁶⁸Ga]Ga-HA-DOTATATE were assessed and subsequently [¹⁷⁷Lu]Lu-HA-DOTATATE was predicted based on [⁶⁸Ga]Ga-HA-DOTATATE imaging.

Methods

A semi-physiological nonlinear mixed-effects model was developed for [⁶⁸Ga]Ga-HA-DOTATATE and [¹⁷⁷Lu]Lu-HA-DOTATATE, including six compartments (representing blood, spleen, kidney, tumor lesions, other somatostatin receptor expressing organs and a lumped rest com

SUBMITTER: Siebinga H 

PROVIDER: S-EPMC10449733 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature