Feasibility and safety of non-contrast optical coherence tomography imaging using hydroxyethyl starch in coronary arteries.

ABSTRACT: Intracoronary optical coherence tomography (OCT) requires injection of flushing media for image acquisition. Alternative flushing media needs to be investigated to reduce the risk of contrast-induced renal dysfunction. We investigated the feasibility and safety of pentastarch (hydroxyethyl starch) for clinical OCT imaging. We prospectively enrolled 43 patients with 70 coronary lesions (46-stented; 24-native). Total 81 OCT pullback pairs were obtained by manual injection of iodine contrast, followed by pentastarch. Each pullback was assessed frame-by-frame using an automated customized lumen contour/stent strut segmentation algorithm. Paired images were compared for the clear image segments (CIS), blood-flushing capability, and quantitative morphometric measurements. Overall image quality,

SUBMITTER: Kang DO 

PROVIDER: S-EPMC10449772 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature