Dataset Information

Feasibility and safety of non-contrast optical coherence tomography imaging using hydroxyethyl starch in coronary arteries.

ABSTRACT: Intracoronary optical coherence tomography (OCT) requires injection of flushing media for image acquisition. Alternative flushing media needs to be investigated to reduce the risk of contrast-induced renal dysfunction. We investigated the feasibility and safety of pentastarch (hydroxyethyl starch) for clinical OCT imaging. We prospectively enrolled 43 patients with 70 coronary lesions (46-stented; 24-native). Total 81 OCT pullback pairs were obtained by manual injection of iodine contrast, followed by pentastarch. Each pullback was assessed frame-by-frame using an automated customized lumen contour/stent strut segmentation algorithm. Paired images were compared for the clear image segments (CIS), blood-flushing capability, and quantitative morphometric measurements. Overall image quality, as assessed by the proportion of CIS, was comparable between the contrast- and pentastarch-flushed images (97.1% vs. 96.5%; p = 0.160). The pixel-based blood-flushing capability was similar between the groups (0.951 [0.947-0.953] vs. 0.950 [0.948-0.952], p = 0.125). Quantitative two- and three-dimensional morphometric measurements of the paired images correlated well (p < 0.001) with excellent inter-measurement variability. All patients safely underwent OCT imaging using pentastarch without resulting in clinically relevant complications or renal deterioration. Non-contrast OCT imaging using pentastarch is clinically safe and technically feasible with excellent image quality and could be a promising alternative strategy for patients at high risk of renal impairment.

SUBMITTER: Kang DO

PROVIDER: S-EPMC10449772 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Feasibility and safety of non-contrast optical coherence tomography imaging using hydroxyethyl starch in coronary arteries.

Kang Dong Oh DO Nam Hyeong Soo HS Kim Sunwon S Yoo Hongki H Kim Jin Won JW

Scientific reports 20230824 1

Intracoronary optical coherence tomography (OCT) requires injection of flushing media for image acquisition. Alternative flushing media needs to be investigated to reduce the risk of contrast-induced renal dysfunction. We investigated the feasibility and safety of pentastarch (hydroxyethyl starch) for clinical OCT imaging. We prospectively enrolled 43 patients with 70 coronary lesions (46-stented; 24-native). Total 81 OCT pullback pairs were obtained by manual injection of iodine contrast, follo ...[more]

PMID: 37620359

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Dataset Information

Feasibility and safety of non-contrast optical coherence tomography imaging using hydroxyethyl starch in coronary arteries.

Publications

Feasibility and safety of non-contrast optical coherence tomography imaging using hydroxyethyl starch in coronary arteries.

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