Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots.

ABSTRACT: While blood clot formation has been relatively well studied, little is known about the mechanisms underlying the subsequent structural and mechanical clot remodeling called contraction or retraction. Impairment of the clot contraction process is associated with both life-threatening bleeding and thrombotic conditions, such as ischemic stroke, venous thromboembolism, and others. Recently, blood clot contraction was observed to be hindered in patients with COVID-19. A three-dimensional multiscale computational model is developed and used to quantify biomechanical mechanisms of the kinetics of clot contraction driven by platelet-fibrin pulling interactions. These results provide important biological insights into contraction of platelet filopodia, the mechanically active thin protrusions of t

SUBMITTER: Michael C 

PROVIDER: S-EPMC10449797 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature