Metal-mediated DNA strand displacement and molecular device operations based on base-pair switching of 5-hydroxyuracil nucleobases.

ABSTRACT: Rational design of self-assembled DNA nanostructures has become one of the fastest-growing research areas in molecular science. Particular attention is focused on the development of dynamic DNA nanodevices whose configuration and function are regulated by specific chemical inputs. Herein, we demonstrate the concept of metal-mediated base-pair switching to induce inter- and intramolecular DNA strand displacement in a metal-responsive manner. The 5-hydroxyuracil (U^OH) nucleobase is employed as a metal-responsive unit, forming both a hydrogen-bonded U^OH-A base pair and a metal-mediated U^OH-Gd^III-U^OH base pair. Metal-mediated strand displacement reactions are demonstrated under isothermal conditions based on the base-pair switching between

SUBMITTER: Takezawa Y 

PROVIDER: S-EPMC10449808 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature