Fiber supplementation protects from antibiotic-induced gut microbiome dysbiosis by modulating gut redox potential.

ABSTRACT: Antibiotic-induced gut dysbiosis (AID) is a frequent and serious side effect of antibiotic use and mitigating this dysbiosis is a critical therapeutic target. We propose that the host diet can modulate the chemical environment of the gut resulting in changes to the structure and function of the microbiome during antibiotic treatment. Gut dysbiosis is typically characterized by increases in aerobic respiratory bacterial metabolism, redox potential, and abundance of Proteobacteria. In this study, we explore dietary fiber supplements as potential modulators of the chemical environment in the gut to reduce this pattern of dysbiosis. Using defined-diets and whole-genome sequencing of female murine microbiomes during diet modulation and antibiotic treatment, we find that fiber prebiotics signifi

SUBMITTER: Penumutchu S 

PROVIDER: S-EPMC10449846 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature