Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders.

ABSTRACT: Exposure to early life trauma increases the risk of psychopathology later in life. Here we investigated if ANK3 mRNA levels influence the relationship between childhood trauma experiences and clinical characteristics in mental disorders. A sample of 174 patients with bipolar disorder and 291 patients with schizophrenia spectrum disorder were included. Patients were diagnosed using the Structured Clinical Interview for DSM-IV, and childhood trauma was assessed using the childhood trauma questionnaire. Age at illness onset and number of psychotic and affective episodes were assessed from interview and medical records. Current depressive symptoms were measured using the calgary depression scale for schizophrenia and the inventory for depressive symptomatology. ANK3 expression was analyzed in

SUBMITTER: Aas M 

PROVIDER: S-EPMC10449847 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature