Colorectal cancer detected by liquid biopsy 2 years prior to clinical diagnosis in the HUNT study.

ABSTRACT:

Background

Colorectal cancer (CRC) is often diagnosed in advanced stages. Circulating tumour DNA (ctDNA) has been proposed as an early diagnostic biomarker. However, as a screening tool, ctDNA has mainly been studied in selected populations at the time of clinical diagnosis. The aim of this study was to detect CRC by known ctDNA markers up to 2 years prior to clinical diagnosis.

Methods

In this case-control study, methylated ctDNA markers were detected in plasma samples from 106 healthy controls and 106 individuals diagnosed with CRC within 24 months following participation in The Trøndelag Health Study.

Results

The most specific single markers were BMP3, FLI1, IKZF1, SFRP1, SFRP2, NPTX2, SLC8A1 and VIM (specificity >70%). When combining these into a panel, the CRC se

SUBMITTER: Brenne SS 

PROVIDER: S-EPMC10449868 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature