Ontology highlight
ABSTRACT:
SUBMITTER: Sun M
PROVIDER: S-EPMC10449909 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Sun Mayu M Ma Xueqi X Mu Wei W Li Haonan H Zhao Xiaoming X Zhu Tengfei T Li Jingquan J Yang Yongliang Y Zhang Haibing H Ba Qian Q Wang Hui H
Cell death & disease 20230824 8
Necroptosis, a programmed cell death with necrotic-like morphology, has been recognized as an important driver in various inflammatory diseases. Inhibition of necroptosis has shown potential promise in the therapy of multiple human diseases. However, very few necroptosis inhibitors are available for clinical use as yet. Here, we identified an FDA-approved anti-cancer drug, Vemurafenib, as a potent inhibitor of necroptosis. Through direct binding, Vemurafenib blocked the kinase activity of recept ...[more]