Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC10449923 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Li Changpeng C He Jingcai J Meng Fei F Wang Fuhui F Sun Hao H Zhang Huizhong H Dong Linna L Zhang Mengdan M Xu Qiaoran Q Liang Lining L Li Yuan Y Yang Tingting T He Meiai M Wang Tao T Lin Jiechun J Sun Jiaqi J Huang Qiuling Q Guo Lin L Zhang Xiaofei X Mai Shijuan S Zheng Hui H
Cell death & disease 20230824 8
Mutation-induced malfunction of ten-eleven translocation methylcytosine dioxygenase 2 (TET2) is widely reported in haematological malignancies. However, the role of TET2 in solid cancers, including colorectal cancer (CRC), is unclear. Here, we found that TET2 malfunction in CRC is mostly due to decreased nuclear localization and that nuclear localization of TET2 is correlated with better survival of patients. To explore the underlying mechanisms, 14 immortalized solid tumour cell lines and 12 pr ...[more]