Migraine, chronic kidney disease and kidney function: observational and genetic analyses.

ABSTRACT: Epidemiological studies demonstrate an association between migraine and chronic kidney disease (CKD), while the genetic basis underlying the phenotypic association has not been investigated. We aimed to help avoid unnecessary interventions in individuals with migraine through the investigation of phenotypic and genetic relationships underlying migraine, CKD, and kidney function. We first evaluated phenotypic associations using observational data from UK Biobank (N = 255,896). We then investigated genetic relationships leveraging genomic data in European ancestry for migraine (N_case/N_control = 48,975/540,381), CKD (N_case/N_control = 41,395/439,303), and two traits of kidney function (estimated glomerular filtration rate [eGFR, N = 567,460] and urin

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10449948 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature