Night-Time Apomorphine Infusion: Who Are the Best Candidates?

ABSTRACT:

Background

We recently demonstrated in a randomized controlled trial (APOMORPHEE, NCT02940912) that night-time only subcutaneous apomorphine infusion improves sleep disturbances and insomnia in patients with advanced Parkinson's disease and moderate to severe insomnia.

Objectives

To identify the best candidates for receiving night-time only subcutaneous apomorphine infusion in routine care.

Methods

In this post-hoc analysis of APOMORPHEE, we compared the characteristics of patients according to whether they chose to continue night-time only subcutaneous apomorphine infusion at the end of the study period or not.

Results

Half of the patients (22/42) chose to continue the treatment. Off duration (day or night), painful Off dystonia, and insomnia severity at basel

SUBMITTER: Cochen De Cock V 

PROVIDER: S-EPMC10450238 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature