The Role of Levodopa Challenge in Predicting the Outcome of Subthalamic Deep Brain Stimulation.

ABSTRACT:

Background

Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective and evidence-based treatment for idiopathic Parkinson's disease (iPD). A minority of patients does not sufficiently benefit from STN-DBS.

Objective

The predictive validity of the levodopa challenge for individual patients is analyzed.

Methods

Data from patients assessed with a preoperative Levodopa-test and a follow-up examination (mean ± standard deviation: 9.15 months ±3.39) from Kiel (n = 253), Berlin (n = 78) and Toronto (n = 98) were studied. Insufficient DBS outcome was defined as an overall UPDRS-III reduction <33% compared to UPDRS-III in med-off at baseline or alternatively if the minimal clinically important improvement of 5 points was not reached. Single UPDRS-items and s

SUBMITTER: Wolke R 

PROVIDER: S-EPMC10450242 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature