Causal relationship between particulate matter 2.5 and diabetes: two sample Mendelian randomization.

ABSTRACT:

Backgrounds

Many studies have shown particulate matter has emerged as one of the major environmental risk factors for diabetes; however, studies on the causal relationship between particulate matter 2.5 (PM_2.5) and diabetes based on genetic approaches are scarce. The study estimated the causal relationship between diabetes and PM_2.5 using two sample mendelian randomization (TSMR).

Methods

We collected genetic data from European ancestry publicly available genome wide association studies (GWAS) summary data through the MR-BASE repository. The IEU GWAS information output PM_2.5 from the Single nucleotide polymorphisms (SNPs) GWAS pipeline using pheasant-derived variables (Consortium = MRC-IEU, sample size: 423,796). The annual relationship of PM

SUBMITTER: Kim JM 

PROVIDER: S-EPMC10450337 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature