Rectal cancer patients younger than 50 years lack a survival benefit from NCCN guideline-directed treatment for stage II and III disease.

ABSTRACT:

Background

The incidence of rectal cancer in patients younger than 50 years is increasing. To test the hypothesis that the biology in this younger cohort may differ, this study compared survival patterns, stratifying patients according to National Comprehensive Cancer Network (NCCN) guideline-driven care and age.

Methods

The National Cancer Data Base was queried for patients treated with curative-intent transabdominal resections with negative surgical margins for stage I to III rectal cancer between 2004 and 2014. Outcomes and overall survival for patients younger than 50 years and patients 50 years old or older were compared by subgroups based on NCCN guideline-driven care.

Results

A total of 43,106 patients were analyzed. Younger patients were more likely to be fema

SUBMITTER: Kolarich A 

PROVIDER: S-EPMC10450543 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature