Immune Checkpoint Inhibitors for Child-Pugh Class B Advanced Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

Immune checkpoint inhibitors (ICIs) are increasingly used in patients with advanced hepatocellular carcinoma (HCC). However, data on ICI therapy in patients with advanced HCC and impaired liver function are scarce.

Objective

To conduct a systematic review and meta-analysis to determine the efficacy and safety of ICI treatment for advanced HCC with Child-Pugh B liver function.

Data sources

PubMed, Embase, Web of Science, and Cochrane Library were searched for relevant studies from inception through June 15, 2022.

Study selection

Randomized clinical trials, cohort studies, or single-group studies that investigated the efficacy or safety of ICI therapy for Child-Pugh B advanced HCC were included.

Data extraction and synthesis

The Preferred Report

SUBMITTER: Xie E 

PROVIDER: S-EPMC10450588 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature