Synaptic and cellular endocannabinoid signaling mechanisms regulate stress-induced plasticity of nucleus accumbens somatostatin neurons.

ABSTRACT: Interneuron populations within the nucleus accumbens (NAc) orchestrate excitatory-inhibitory balance, undergo experience-dependent plasticity, and gate-motivated behavior, all biobehavioral processes heavily modulated by endogenous cannabinoid (eCB) signaling. While eCBs are well known to regulate synaptic plasticity onto NAc medium spiny neurons and modulate NAc function at the behavioral level, how eCBs regulate NAc interneuron function is less well understood. Here, we show that eCB signaling differentially regulates glutamatergic and feedforward GABAergic transmission onto NAc somatostatin-expressing interneurons (NAc^SOM+) in an input-specific manner, while simultaneously increasing postsynaptic excitability of NAc^SOM+ neurons, ultimately biasing toward vHPC (vent

SUBMITTER: Kondev V 

PROVIDER: S-EPMC10450650 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature