Bioinformatics study on genes related to a high-risk postoperative recurrence of lung adenocarcinoma.

ABSTRACT: In this study, we aimed to screen out genes associated with a high risk of postoperative recurrence of lung adenocarcinoma and investigate the possible mechanisms of the involvement of these genes in the recurrence of lung adenocarcinoma. We identify Hub genes and verify the expression levels and prognostic roles of these genes. Datasets of GSE40791, GSE31210, and GSE30219 were obtained from the Gene Expression Omnibus database. Enrichment analysis of gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were performed for the screened candidate genes using the DAVID database. Then, we performed protein-protein interaction (PPI) network analysis through the database STRING. Hub genes were screened out using Cytoscape software, and their expression levels were determined

SUBMITTER: Lin X 

PROVIDER: S-EPMC10450722 | biostudies-literature | 2021 Jul-Sep

REPOSITORIES: biostudies-literature