Mouse maternal odontogenic infection with Porphyromonas gingivalis induces cognitive decline in offspring

ABSTRACT:

Introduction

Porphyromonas gingivalis (P. gingivalis), a major periodontal pathogen, causes intrauterine infection/inflammation. Offspring exposed to intrauterine infection/inflammation have an increased risk of neurological disorders, regardless of gestational age. However, the relationship between maternal periodontitis and offspring functional/histological changes in the brain has not yet been elucidated.

Methods

In this study, we used a gestational mouse model to investigate the effects of maternal odontogenic infection of P. gingivalis on offspring behavior and brain tissue.

Results

The step-through passive avoidance test showed that the latency of the acquisition trial was significantly shorter in the P. gingivalis group (p < 0.05), but no difference in spo

SUBMITTER: Ishida E 

PROVIDER: S-EPMC10450928 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature