Myeloid-associated differentiation marker is associated with type 2 asthma and is upregulated by human rhinovirus infection.

ABSTRACT:

Background

Human rhinoviruses are known to predispose infants to asthma development during childhood and are often associated with exacerbations in asthma patients. MYADM epithelial expression has been shown to associate with asthma severity. The goal of this study was to determine if MYADM expression patterns were altered in asthma and/or rhinovirus infection and if increased MYADM expression is associated with increased asthma-associated factors.

Methods

Utilizing H1HeLa cells and differentiated primary human airway epithelial cells (AECs), we measured the expression of MYADM and inflammatory genes by qRT-PCR in the presence or absence of RV-1B infection or poly I:C treatment and with siRNA knockdown of MYADM. Expression of MYADM in the asthmatic lung was determined in the

SUBMITTER: Tanyaratsrisakul S 

PROVIDER: S-EPMC10450947 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature