Hydrogel degradation promotes angiogenic and regenerative potential of cell spheroids for wound healing.

ABSTRACT: Chronic nonhealing wounds are debilitating and diminish one's quality of life, necessitating the development of improved strategies for effective treatment. Biomaterial- and cell-based therapies offer an alternative treatment compared to conventional wound care for regenerating damaged tissues. Cell-based approaches frequently utilize endothelial cells (ECs) to promote vascularization and mesenchymal stromal cells (MSCs) for their potent secretome that promotes host cell recruitment. Spheroids have improved therapeutic potential over monodisperse cells, while degradable scaffolds can influence cellular processes conducive to long-term tissue regeneration. However, the role of biomaterial degradation on the therapeutic potential of heterotypic EC-MSC spheroids for wound healing is largely u

SUBMITTER: Thai VL 

PROVIDER: S-EPMC10450977 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature