<i>Klebsiella pneumoniae</i> manipulates human macrophages to acquire iron.

ABSTRACT:

Background

Klebsiella pneumoniae (KP) is a major cause of hospital-acquired infections, such as pneumonia. Moreover, it is classified as a pathogen of concern due to sprawling anti-microbial resistance. During infection, the gram-negative pathogen is capable of establishing an intracellular niche in macrophages by altering cellular metabolism. One factor critically affecting the host-pathogen interaction is the availability of essential nutrients, like iron, which is required for KP to proliferate but which also modulates anti-microbial immune effector pathways. We hypothesized, that KP manipulates macrophage iron homeostasis to acquire this crucial nutrient for sustained proliferation.

Methods

We applied an in-vitro infection model, in which human macrophage-l

SUBMITTER: Grubwieser P 

PROVIDER: S-EPMC10451090 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature