Gestational Age-Dependent Regulation of Transthyretin in Mice during Pregnancy

ABSTRACT:

Simple Summary

Preeclampsia is a severe pregnancy complication with a high incidence of maternal and fetal morbidity and mortality. Our work has demonstrated that preeclampsia shares the etiology of protein misfolding and aggregation with neurodegenerative diseases such as Alzheimer’s. We identified that transthyretin, a transporter of thyroxine and retinol, was a key component in the protein complex in the preeclampsia placenta. However, how TTR is regulated during pregnancy is not clear. In this study, we show that transthyretin is temporally downregulated in the liver and the placenta in pregnant mice and that inflammation may further orchestrate its further downregulation. Importantly, the levels of transthyretin are normalized postpartum. This research provides important insi

SUBMITTER: Cheng S 

PROVIDER: S-EPMC10451295 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature