Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?

ABSTRACT: Although the trigger for the neurodegenerative disease process is unknown, the relevance of aging stands out as a major risk for the development of neurodegeneration. In this review, we highlighted the relationship between the different cellular mechanisms that occur as a consequence of aging and transcription factor nuclear factor erythroid-2-related factor 2 (NRF2) and the connection with the TAU protein. We focused on the relevance of NRF2 in the main processes involved in neurodegeneration and associated with aging, such as genomic instability, protein degradation systems (proteasomes/autophagy), cellular senescence, and stem cell exhaustion, as well as inflammation. We also analyzed the effect of aging on TAU protein levels and its aggregation and spread process. Finally, we investiga

SUBMITTER: Brackhan M 

PROVIDER: S-EPMC10451380 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature