Severity Classification of Laboratory Animal Procedures in Two Belgian Academic Institutions.

ABSTRACT: According to the EU Directive 2010/63, all animal procedures must be classified as non-recovery, mild, moderate or severe. Several examples are included in the Directive to help in severity classification. Since the implementation of the Directive, different publications and guidelines have been disseminated on the topic. However, due to the large variety of disease models and animal procedures carried out in many different animal species, guidance on the severity classification of specific procedures or models is often lacking or not specific enough. The latter is especially the case in disease models where the level of pain, suffering, distress and lasting harm depends on the duration of the study (for progressive disease models) or the dosage given (for infectious or chemically induced

SUBMITTER: De Vleeschauwer S 

PROVIDER: S-EPMC10451636 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature