Protein Kinase C at the Crossroad of Mutations, Cancer, Targeted Therapy and Immune Response.

ABSTRACT: The frequent PKC dysregulations observed in many tumors have made these enzymes natural targets for anticancer applications. Nevertheless, this considerable interest in the development of PKC modulators has not led to the expected therapeutic benefits, likely due to the complex biological activities regulated by PKC isoenzymes, often playing ambiguous and protective functions, further driven by the occurrence of mutations. The structure, regulation and functions of PKCs have been extensively covered in other publications. Herein, we focused on PKC alterations mostly associated with complete functional loss. We also addressed the modest yet encouraging results obtained targeting PKC in selected malignancies and the more frequent negative clinical outcomes. The reported observations advocate

SUBMITTER: Aquino A 

PROVIDER: S-EPMC10451643 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature