MicroRNA miR-263b-5p Regulates Developmental Growth and Cell Association by Suppressing Laminin A in Drosophila

ABSTRACT:

Simple Summary

The basement membrane (BM) plays a crucial role in various biological processes as a thin layer of the extracellular matrix located at the basal surface of tissues. BMs are regulated by physiological conditions that are altered during development. Specifically, tissue remodeling during metamorphosis in Ecdysozoa is closely associated with BM degradation. However, the mechanisms underlying the regulation of the BM remain unclear. Here, we revealed that the upregulation of the metamorphosis-related microRNA-263b inhibits cell association in the larval fat body by suppressing the expression of Laminin A, which is a major component of the BM. This regulatory mechanism is linked to the developmental growth in Drosophila. Overall, our results provide valuable insights int

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PROVIDER: S-EPMC10451713 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature