Gatifloxacin Loaded Nano Lipid Carriers for the Management of Bacterial Conjunctivitis.

ABSTRACT: Bacterial conjunctivitis (BC) entails inflammation of the ocular mucous membrane. Early effective treatment of BC can prevent the spread of the infection to the intraocular tissues, which could lead to bacterial endophthalmitis or serious visual disability. In 2003, gatifloxacin (GTX) eyedrops were introduced as a new broad-spectrum fluoroquinolone to treat BC. Subsequently, GTX use was extended to other ocular bacterial infections. However, due to precorneal loss and poor ocular bioavailability, frequent administration of the commercial eyedrops is necessary, leading to poor patient compliance. Thus, the goal of the current investigation was to formulate GTX in a lipid-based drug delivery system to overcome the challenges with the existing marketed eyedrops and, thus, improve the manageme

SUBMITTER: Joshi PH 

PROVIDER: S-EPMC10451836 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature