Peroxiredoxins Play an Important Role in the Regulation of Immunity and Aging in Drosophila.

ABSTRACT: Aberrant immune responses and chronic inflammation can impose significant health risks and promote premature aging. Pro-inflammatory responses are largely mediated via reactive oxygen species (ROS) and reduction-oxidation reactions. A pivotal role in maintaining cellular redox homeostasis and the proper control of redox-sensitive signaling belongs to a family of antioxidant and redox-regulating thiol-related peroxidases designated as peroxiredoxins (Prx). Our recent studies in Drosophila have shown that Prxs play a critical role in aging and immunity. We identified two important 'hubs', the endoplasmic reticulum (ER) and mitochondria, where extracellular and intracellular stress signals are transformed into pro-inflammatory responses that are modulated by the activity of the Prxs re

SUBMITTER: Odnokoz O 

PROVIDER: S-EPMC10451867 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature