Ruta graveolens: Boost Melanogenic Effects and Protection against Oxidative Damage in Melanocytes.

ABSTRACT: Vitiligo, an acquired depigmentation disorder, is characterized by the loss of functional melanocytes and epidermal melanin. In recent years, research has focused on promoting melanin biosynthesis and protecting melanocytes to reduce stress-related damage for the purpose of applying it to vitiligo treatment. Ruta graveolens L. has been utilized as a medicinal herb in diverse traditional medicine systems to address conditions like vitiligo. In this investigation, we isolated and purified 16 unique alkaloid compounds from the chloroform extracts of R. graveolens, encompassing a new quinoline alkaloid and several recognized compounds. Bioactivity analysis showed that compound 13, an alkaloid derived from R. graveolens, promotes melanin production while protecting P

SUBMITTER: Ainiwaer P 

PROVIDER: S-EPMC10451875 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature